But these drugs can be habit-forming, so they should be used rarely and only for a short time. This drug passes into breast milk and may have undesirable effects on a nursing infant. Avoid breastfeeding for at least 12 hours after using sumatriptan. Consult your doctor before breast-feeding. Use lists, notes, and other helpful devices as reminders. Who should not take IMITREX? MAO-A inhibitor on the bioavailability from a 25-mg oral sumatriptan tablet resulted in an approximately 7-fold increase in systemic exposure. anafranil
Imitrex Injection is not indicated for the prevention of migraine or cluster headache attacks. Your doctor may ask you to take the first dose in the office. The name of your medicine is IMITREX sumatriptan succinate Injection. It can be obtained only by prescription from your doctor. The decision to use IMITREX Injection is one that you and your doctor should make jointly, taking into account your individual preferences and medical circumstances. If you have risk factors for heart disease such as high blood pressure, high cholesterol, obesity, diabetes, smoking, strong family history of heart disease, or you are postmenopausal or a male over 40 you should tell your doctor, who should evaluate you for heart disease in order to determine if IMITREX is appropriate for you. Although the vast majority of those who have taken IMITREX have not experienced any significant side effects, some individuals have experienced serious heart problems and, rarely, considering the extensive use of IMITREX worldwide, deaths have been reported. In all but a few instances, however, serious problems occurred in people with known heart diseases and it was not clear whether IMITREX was a contributory factor in these deaths.
If you are taking a liquid product, use a medication-measuring device to carefully measure the dose. Do not use a household spoon. Some liquid products need to be shaken before each dose. Some products that contain need to be placed under the and held there before swallowing. Follow label directions carefully to get the most benefit. Due to gut and hepatic metabolic first-pass effects, the increase of systemic exposure after co-administration of an MAO-A inhibitor with oral sumatriptan is greater than after co-administration of the MAO inhibitors with subcutaneous sumatriptan. The studies did not establish the efficacy of sumatriptan nasal spray compared to placebo in the treatment of migraine in adolescents. Adverse events observed in these clinical trials were similar in nature to those reported in clinical trials in adults.
Store Imitrex tablets between 36 and 86 degrees F 2 and 30 degrees C. Store away from heat, moisture, and light. Do not freeze. Do not store at temperatures above 86 degrees F 30 degrees C. Do not store in the bathroom. Keep Imitrex tablets in the case provided. Throw away expired medicine as directed by your doctor the expiration date is printed on the treatment pack. Keep Imitrex tablets out of the reach of children and away from pets. The injection is intended to be given subcutaneously, and intramuscular or intravascular delivery must be avoided. Instruct patients on the proper use of IMITREX STATdose Pen and direct them to use injection sites with an adequate skin and subcutaneous thickness to accommodate the length of the needle.
For subcutaneous injection only. How should I take Imitrex? Store your medicine away from light. Check your pressure regularly and tell your doctor if the results are high. Men get them more than women do. You usually start getting them before you're age 30. Cluster headaches may disappear completely go into remission for months or years, but they can come back without any warning. The Pen is used to automatically inject 1 dose of medicine from a Syringe Cartridge. Do not touch this area again before giving the injection. Five controlled clinical trials 2 single attack studies, 3 multiple attack studies evaluating oral sumatriptan 25 to 100 mg in pediatric patients aged 12 to 17 years enrolled a total of 701 adolescent migraineurs. These studies did not establish the efficacy of oral sumatriptan compated to placebo in the treatment of migraine in adolescents. Adverse events observed in these clinical trials were similar in nature to those reported in clinical trials in adults. The frequency of all adverse events in these patients appeared to be both dose- and age-dependent, with younger patients reporting events more commonly than older adolescents. The maximum single recommended adult dose of IMITREX Injection is 6 mg injected subcutaneously. Controlled clinical trials have failed to show that clear benefit is associated with the administration of a second 6-mg dose in patients who have failed to respond to a first injection. This Patient Information leaflet summarizes the most important information about IMITREX. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about IMITREX that is written for healthcare professionals. Certain conditions can increase your risk for problems.
The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Increase in Blood Pressure: Significant elevation in blood pressure, including hypertensive crisis, has been reported on rare occasions in patients with and without a history of hypertension. Sumatriptan is contraindicated in patients with uncontrolled hypertension see . Sumatriptan should be administered with caution to patients with controlled hypertension as transient increases in blood pressure and peripheral vascular resistance have been observed in a small proportion of patients. Rami Burstein, PhD, of Beth Israel Medical Center and Harvard Medical School, in a news release. This medication should not be taken if you have certain medical conditions. HGPRT assay. In 2 cytogenetics assays the in vitro human lymphocyte assay and the in vivo rat micronucleus assay sumatriptan was not associated with clastogenic activity. Do not discard the auto-injector. You may use it again with refills of the prefilled syringes. However, if you are using a one-time use auto-injector, discard the auto-injector after use. If you are unsure if your auto-injector can be re-used, ask your pharmacist. Keep all medicines away from children and pets. Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HT 1 agonists. Discontinue Imitrex Injection if these disturbances occur. Imitrex Injection is contraindicated in patients with Wolff-Parkinson-White syndrome or arrhythmias associated with other cardiac accessory conduction pathway disorders. Alcohol: Alcohol consumed 30 minutes prior to sumatriptan ingestion had no effect on the pharmacokinetics of sumatriptan. This drug passes into breast milk in small amounts. Consult your doctor before breast-feeding. Side Effects List Sumatriptan-Naproxen Tablet side effects by likelihood and severity. Table 3, onset of relief began as early as 10 minutes following a 6-mg Imitrex Injection. Lower doses of Imitrex Injection may also prove effective, although the proportion of patients obtaining adequate relief was decreased and the latency to that relief is greater with lower doses. fosamax
If not, I eat something and take the rest of the pill about an hour later. Mild or flushing may occur. These effects are usually temporary and may disappear as your body adjusts to this product. If any of these effects persist or worsen, contact your doctor or promptly. This product is safe to take during when used as directed. Certain spinal cord may be prevented by maintaining adequate amounts of during pregnancy. Consult your doctor or pharmacist for details. Medication overuse headache may present as migraine-like daily headaches or as a marked increase in frequency of migraine attacks. Detoxification of patients, including withdrawal of the overused drugs, and treatment of withdrawal symptoms which often includes a transient worsening of headache may be necessary. You tend to get them at the same time each year, such as the spring or fall. Because of their seasonal nature, people often mistake for or business stress. IMITREX. Such reactions can be life threatening or fatal. In general, anaphylactic reactions to drugs are more likely to occur in individuals with a history of sensitivity to multiple allergens. Imitrex Injection is contraindicated in patients with a history of hypersensitivity reaction to IMITREX. Miscellaneous: Contusions, difficulty in walking, edema, hematoma, hypersensitivity, fever, fluid retention, lymphadenopathy, overdose, speech disturbance, swelling of extremities, swelling of face, and voice disturbances. omca.info tricor
IMITREX STAT dose Pen. Cartridge Pack out of the Carrying Case. Some sumatriptan side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. You may have to try different drugs or doses. If you have already tried several medicines, your doctor may order tests such as an or to find out if a health problem is causing your headaches. TIA. Discontinue Imitrex Injection if a cerebrovascular event occurs. Serotonin syndrome is a possibly fatal syndrome that can be caused by Imitrex tablets. Your risk may be greater if you take Imitrex tablets with certain other medicines eg, SSRIs, SNRIs. Symptoms may include agitation; confusion; hallucinations; coma; fever; fast or irregular heartbeat; tremor; excessive sweating; and nausea, vomiting, or diarrhea. Contact your doctor at once if you have any of these symptoms. Tell your doctor if you are or if you plan to become pregnant. how to buy adapalene canada
There were no differences in relief rates at 60 minutes postdose for IMITREX Injection, whether or not prophylactic medications were used. If migraine returns after an initial dose of subcutaneous injection, additional oral doses may be given up to 100 mg orally per day, with at least a 2 hour interval between tablet doses. Use Imitrex spray as directed by your doctor. Check the label on the medicine for exact dosing instructions. Seizures have been reported in patients with either a history of seizures or concurrent conditions predisposing to seizures and also in patients where no such predisposing factors are apparent. How long does it last? The efficacy of Imitrex Injection in the acute treatment of cluster headache was demonstrated in 2 randomized, double-blind, placebo-controlled, 2-period crossover trials Studies 4 and 5. Patients 21 to 65 years of age were enrolled and were instructed to treat a moderate to very severe headache within 10 minutes of onset. Headache relief was defined as a reduction in headache severity to mild or no pain.
Injection: 6-mg single-dose vial. Your blood pressure will need to be checked often. If the migraine has not resolved by 2 hours after taking Imitrex Tablets, or returns after a transient improvement, a second dose may be administered at least 2 hours after the first dose. The maximum daily dose is 200 mg in a 24-hour period. Read the Patient Information Leaflet if available from your pharmacist before you start taking sumatriptan and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Another study of 125 patients concluded that panic-like symptoms may explain the chest pain and related side effects after sumatriptan administration in patients with high levels of anxiety. My diarrhea came as the result of returning to eating more "normal" food, after being on the "Very Low Calorie Diet" VLCD phase of the hcg diet. I'm not talking about suddenly eating at Taco Bell. Drowsiness may occur during a migraine or during its treatment with this drug. Do not drive or operate machinery until you know how this drug affects you. The plot was constructed with data from patients who either experienced relief or did not require request rescue medication within a period of 2 hours following treatment. As a consequence, the data in the plot are derived from only a subset of the 258 headaches treated rescue medication was required in 52 of the 127 placebo-treated headaches and 18 of the 131 sumatriptan-treated headaches. generic casodex buy online shop
The fact that sumatriptan can cause coronary vasospasm, that some of these events have occurred in patients with no prior cardiac disease history and with documented absence of CAD, and the close proximity of the events to sumatriptan use support the conclusion that some of these cases were caused by the drug. In many cases, however, where there has been known underlying CAD, the relationship is uncertain. Oral administration of sumatriptan to pregnant rabbits during the period of organogenesis resulted in increased incidences of embryolethality and fetal cervicothoracic vascular and skeletal abnormalities. Intravenous administration of sumatriptan to pregnant rabbits during the period of organogenesis resulted in an increased incidence of embryolethality. Food and Drug Administration. These trials did not establish the efficacy of oral Imitrex compared with placebo in the treatment of migraine in adolescents. Adverse reactions observed in these clinical trials were similar in nature to those reported in clinical trials in adults. IMITREX Injection is a clear, colorless to pale yellow, sterile, nonpyrogenic solution for subcutaneous injection. The unit contains only 1 spray. Do NOT test it before use. You should take preventive medicine, unless your headache periods last less than 2 weeks. Autoinjector Pen: Each pack contains a and Instructions for Use leaflet. Do not use IMITREX Injection if you are pregnant, think you might be pregnant, are trying to become pregnant, or are not using adequate contraception, unless you have discussed this with your doctor. GSK group of companies. price pyrantel reviews
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Drug Interactions: Monoamine Oxidase Inhibitors: In vitro studies with human microsomes suggest that sumatriptan is metabolized by monoamine oxidase MAO predominantly the A isoenzyme. In a study of 14 healthy females, pretreatment with MAO-A inhibitor decreased the clearance of sumatriptan. IMITREX in their causation cannot be reliably determined. All reported events are included except those already listed, those too general to be informative, and those not reasonably associated with the use of the drug. Dogs receiving oral sumatriptan developed corneal opacities and defects in the corneal epithelium. cash price for cyproheptadine dose pack
Neurological: Infrequent were mental confusion, euphoria, agitation, relaxation, chills, sensation of lightness, tremor, shivering, disturbances of taste, prickling sensations, paresthesia, stinging sensations, facial pain, photophobia, and lacrimation. Have you ever had to stop taking this or any other medicine because of an allergy or other problems? The clinical significance of this binding is unknown. Ottervanger JP, van Witsen TB, Valkenburg HA, Stricker BH "Postmarketing study of cardiovascular adverse reactions associated with sumatriptan. Cardiac events that have been observed to have onset within 1 hour of sumatriptan administration include: coronary artery vasospasm, transient ischemia, myocardial infarction, ventricular tachycardia and ventricular fibrillation, cardiac arrest, and death. armidex
Do not flush down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Complete the What is a document? Swallow Imitrex tablets whole. Do not break, crush, or chew before swallowing. It's so bad that most people can't sit still and will often pace during an attack.
If your migraine symptoms go away and then come back, or if you have a partial response to the first dose, you may take a second dose as directed by your doctor. Wait at least 2 hours between doses. It is unknown what effect hemodialysis or peritoneal dialysis has on the serum concentrations of sumatriptan. Tablets: White, triangular-shaped, film-coated, and debossed with “I” on one side and “25” on the other. Renal Impairment: The effect of renal impairment on the pharmacokinetics of sumatriptan has not been examined. Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.